Patients undergoing open heart surgery in the afternoon have a lower risk of potentially fatal complications than those undergoing operations in the morning, new research suggests.
The study found that events including heart attacks and heart failure were less common among those who had undergone a valve replacement operation in the afternoon.
The finding appears to be linked to the ability of the heart tissue to recover after being starved of blood supply during surgery – an effect the researchers say is influenced by the cells’ biological or “circadian” clock.
While the study suggests patients might fare better if they undergo afternoon surgery, Professor David Montaigne, first author of the research from the University of Lille in France, said it also highlighted another approach to reduce complications.
“We have to find a drug that can alter the circadian clock to induce a jet lag,” he said, noting that it could also help to improve patient outcomes for heart attacks and organ transplantation.
Writing the in Lancet, Montaigne and colleagues report how they looked at the outcomes of 596 patients, half of whom had valve surgery in the morning, and half in the afternoon. While 18% of morning surgery patients experienced a major cardiac event – such.
source : sky news