The\u00a0ER\u00a0actress who claimed George Clooney helped blacklist her from Hollywood has been\u00a0shot and killed\u00a0by police in\u00a0Southern California.\u00a0\r\nPolice say Vanessa\u00a0Marquez, 49, she pointed a replica handgun at them during a welfare check.\u00a0\r\nShe died at a hospital following Thursday's shooting at her apartment in South Pasadena, just outside Los Angeles, police said.Officers were responding to a call from Marquez's landlord that she needed medical help when they found her having a seizureParamedics treated Marquez, who improved and began talking with three officers and a mental health clinician, who spent an hour and a half trying to talk her into getting additional medical help, Lt\u00a0Joe\u00a0Mendoza\u00a0of\u00a0the Los Angeles County Sheriff's Department, said.\r\nAccording to police,\u00a0Marquez became uncooperative\u00a0and at some point pointed what\u00a0turned out to be a BB gun at the officers, prompting two of them to shoot.\r\nThe officers were wearing body cameras but footage won't be released for at least six months pending the investigation, Mendoza said.\r\nClose friend of Marquez\u00a0Terence Towles\u00a0Canote\u00a0said the actress was having health and financial problems, but that she showed no signs of depression.\r\nShe was hopeful for a career comeback despite her medical struggles, he said.\r\n"She was looking forward to life," Canote said. "This is not a woman who wanted to die."\r\nMarquez posted extensively on Facebook and in other outlets about her health problems, saying she was terminally ill and had seizures and celiac disease, an autoimmune disorder that can damage the small intestine with the ingestion of gluten.\r\nIn 2014, she said in an online post that she had spent her entire life savings on doctors and hospitals who didn't properly treat her and that she couldn't work or "do most basic everyday functions."\r\nMarquez gained attention last year after tweeting that George Clooney helped blacklist her from Hollywood when she complained about sexual harassment and racist comments among their\u00a0ER\u00a0co-stars. Clooney said in a statement to\u00a0US Weekly\u00a0at the time that he was just an actor on the show and was unaware of any blacklist.\r\n"If she was told I was involved in any decision about her career then she was lied to," he said. "The fact that I couldn't affect her career is only surpassed by the fact that I wouldn't."\r\nMarquez also appeared on episodes of\u00a0Seinfeld,\u00a0Melrose Place\u00a0and\u00a0Malcolm &Eddie\u00a0but her career largely fizzled after\u00a0ER.\r\nOne of her posts talked about being grateful to be a part of\u00a0Stand and Deliver,\u00a0a 1988 film about a math teacher who motivated struggling students at a tough East Los Angeles high school.\r\n"If you're truly fortunate, you get to live your dream and do the work you were put on this Earth to do," she wrote. "If you're really, really fortunate you do a film that makes history and affects the lives of millions of people ... It will live on long after we're gone."