New compound may kill hard-to-treat cancer cells2 June, 2022
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Cancer is one of the leading causes of death in the world, and this disease poses a challenge to researchers and scientists in order to find more effective treatments and drugs in eliminating different types of cancer.
In this context, researchers from the University of Texas Health Sciences Center have developed a new compound that kills a group of cancers that are difficult to treat in animal models.
A study published in the journal Nature Cancer showed that this compound targets a weakness in cancer cells that other treatments have never targeted.
The researchers indicated that this compound can be used to fight cancers that current treatments are unable to kill. They identified a critical weakness in many cancers, and validated their findings in many types of cancer cells and animal models.
In addition, researchers have studied the development of breast and ovarian cancer, including treatment resistance, with the aim of developing small-molecule inhibitors of treatment-resistant cancers.
And in 2017, the research team identified a compound called “ERX-11” that targets the estrogen receptor (ER), a protein responsible for the vast majority of breast cancers. Not only does this compound kill estrogen-positive cancers in petri dishes, but it also easily kills Triple-negative breast cancers — cancers that are resistant to hormonal treatments — include more than 20 distinct types of cancer that are rarely successful with conventional treatments.
Other trials have shown that in addition to breast cancers, the compound is also effective against other cancers including pancreatic cancer, glioblastoma and ovarian cancer, all of which have few effective treatments.Other trials have shown that in addition to breast cancers, the compound is also effective against other cancers including pancreatic cancer, glioblastoma and ovarian cancer, all of which have few effective treatments.
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