New hope for breast cancer treatment.. Researchers design an enzyme that may kill the toughest species!!

15 June, 2022
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New hope for breast cancer treatment.. Researchers design an enzyme that may kill the toughest species!!

With continued hope of finding a cure for cancer, researchers at the University of Texas have synthesized a new molecule that kills a wide range of hard-to-treat cancers, including triple-negative breast cancer.

Jung Moo-an, a co-author of the study, designed small molecules that target protein interactions in cells.

Jung and colleagues tested a new enzyme, called ERX-41, that affects breast cancer cells, both those with and without estrogen receptors.

Although there are effective treatments available for patients with positive breast cancer, treatment options are few for patients with triple negative breast cancer, who lack estrogen and progesterone receptors. The new enzyme stresses the endoplasmic reticulum, a complex network of apoptotic membranes located within the cytoplasm of a eukaryotic cell, leading to cell death.

This opens a large therapeutic window, with no adverse effects on normal breast epithelial cells.

The study, published on the "GEN" website, indicates that ERX-41 does not kill healthy cells, but it kills cancer cells regardless of whether they contain estrogen receptors. "It took us several years to hunt down exactly the protein that was affected by ERX-41, and that was the hard part," Jung Moo Ahn said.

He continued: "Triple negative breast cancer is particularly malignant, it targets women at younger ages, it is aggressive and resistant to treatment. I am really happy that we have discovered something that has the potential to make a huge difference for these patients."


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