New method of chemotherapy relieves pain in cancer patients5 October, 2022
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A French study opened the way for a protocol that makes chemotherapy for cancer patients simpler by adopting subcutaneous injections, instead of intravenous injections that are currently used, if this method proves effective in humans after testing on animals.
Cancer treatment is often based on intravenous chemotherapy, which generates many health consequences and requires hospitalization for the patient.
However, a study conducted in France on animals and published by the "American Chemical Society" gave hope to make the procedure more simplified. One possibility that she notes for facilitating treatment is the introduction of subcutaneous chemotherapy. Resorting to this method, which is more easy to implement and less inconvenience to the patient, remains most of the time not possible because the active components of the treatment tend to stagnate in the subcutaneous tissue and cause necrosis due to its high toxicity.
Scientists have come up with a new approach that aims to overcome this obstacle, by attaching the low-soluble active ingredient “paclitaxel”, which is widely used in chemotherapy, to a polymer that is characterized by its strong compatibility with water. It passes quickly from the subcutaneous tissue into the bloodstream without causing toxicity at the site of injection. During preclinical trials of this new chemotherapy in mice, the scientists found that it was more effective than the commercial formulation of the active ingredient (Taxol) given intravenously.
As the lead author of the study, Director of Research at the French National Center for Scientific Research (CNRS), Julien Nicolas, said in a statement to Agence France-Presse that "chemotherapy has many logistical requirements (such as providing qualified staff, hospitalization, etc.), and a high cost", stressing that "the main benefit This new approach is to facilitate chemotherapy and enhance the comfort of patients who may be able to receive treatment at home."
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